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Prion transmitted diseases similar to Creutzfeldt-Jakob Disease seem to be not that rare in nature. You need to cook the brains extremely well and long to be on the safe side.

Thankfully BSE (Mad Cow Disease) was not as transmissible as feared.

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Prions are proteins and need to be denatured to be rendered harmless. Cooking is generally not enough to achieve this. See WHO guidelines for prion sterilization as mentioned in the Wikipedia article https://en.wikipedia.org/wiki/Prion#Sterilization.

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