Of course, but you should figure out what specifically you're looking for beyond what you've described.
Do you care about tax implications? Are you planning to rent or own a home? Do you have friends or family in any of these areas?
If you haven't traveled much I'd recommend doing it.
This is the most accurate map breaking down regions in the United States in my opinion: https://i.redd.it/q79o3qo8zz991.png
Just for reference, here is a 'cleaner' version that most people like: https://i.redd.it/y4pxyq5eslh51.png
> ... and/or how we’d go about finding it
Others in this thread have some good search ideas but personally I'd start at the top and narrow it down from there.
If you go to https://www.naco.org/ and click on `county explorer` you can filter the map on a county level across a bunch of different dimensions.
I'd definitely limit your choice to places with high internet speeds, good education, growing population, high scoring infrastructure, etc.
Just keep pruning down until you find a few you think you'd like.
> ideas for cities
I could list dozens but maybe check out: Beaver, PA; Mason, MI; Wilson, NC; College Station, TX; Macomb, IL
Assuming your wife is willing to drive some then: Longview, WA; Castle Dale, UT; Wisconsin Rapids, WI;