I tried a full time job and moonlighting, exhausted, in the end I left the job and did contracting for a few years, just too hard to handle both in parallel.

I then tried the 9-5 plus startup game after work, it's less stressing on the workload side(I can manage my startup time unlike the moonlighting where clients sometimes have deadlines), but the even bigger hassle now is interrupts from kids, it's impossible to stay focused when I'm at home due to that.

I respect anyone that has a few kids while having a 9-5 while somehow can take a startup off the ground.

For those who devoted to career without kids or even marriage, we're in a different world, and there is not much for apple to apple comparison.