The author specifically talks about that in the article saying that you can catch "leaving a page" and notify the user that there's still something pending and data would be lost.

And in the case of a big error, you can either refresh the page.. or clear the models and resend them in json format to stay sync with the server. It might be a little more complicated, but with a good framework, not that much more. I.e. multithreaded code is a pain.. asynchronous or not, it's a pain. And, in the rare case where you really need to wait for the server to answer back, well, use a loader. But there's a difference between using a loader when you absolutely need it, and everywhere. Think of how apps work on the desktop.. everything is lighting fast, but in some rare occasions, it blocks. What is better? Something that always block or something that sometime block?