I went to college with a guy who ended up being a successful stand-up (multiple Netflix specials - level). He wasn't terribly funny in college - his brother was much, much funnier. Also watching his first bits on TV - first late night basic cable, then Letterman and Leno and then eventually his specials, he was not good at first and he was not a natural.

My big takeaway from that was that comedy, like many, many things is a skill that can be improved on with hard work. Undoubtedly there is some element of innate talent, but it is far less than I would have imagined before.