What I'm trying to understand: are you talking about when you ask Fusion 360 to do something expensive the UI stops responding for a bit? I certainly see that, but it's not Qt that is the source of problems.
Do you work with huge models?
For hobbyist stuff at least Fusion is by far the least painful option, but the bar is set really, really low. FreeCAD is a gigantic clusterfuck to put it charitably (akin to using an awl to carve a drawing out of cardboard versus pencil and paper). OpenSCAD is neat but it really suffers because OpenSCAD is basically developed and maintained by a single person.
I think it's less true now, but I remember KDE (Qt-based) being slower and buggier than gnome (Gtk-based) a couple of years ago, just to cite one thing. It just felt like Qt-based stuff was in general more of a pain to use & heavier than GTK based stuff. It's really a matter of personal preference here and Qt is a nice project, just that I have some criticism here regarding performance choices. I feel like bad performance decisions tend to snowball and get multiplied when people make library choices and add their own performance issues on top.
Because you included it in a list that otherwise only contained web tech frameworks. It’s not clear to me why you think those are peers of Qt and implied to me that you think they are near equivalents.