UI: whereas Metaflow provides the ability to build your own result visualizations explicitly in your workflow (via their "cards" feature), Sematic makes it so that your outputs (and inputs) get automatic rich visualizations based on the data type of the data being passed around.
API: Instead of being based around explicitly building up a graph, where you have to explicitly specify the I/O connections between steps, Sematic makes defining your steps look like writing/calling python functions.
Packaging: Whereas metaflow requires you to include packaging information in the code defining your steps (the @conda decorator, etc.), Sematic plugs into your existing dependency management to bundle up dependencies for execution in the cloud.