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NAD supplementation is a contested area of research, and there are many studies showing that it doesn't achieve anything useful. Further, NAD supplementation puts stress on the methylation cycle and given that you have a 10-25% chance of an MTHFR mutation (depending on your demographic) you should be very careful with NAD supplementation.

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Can you elaborate on the MTHFR mutation? I did supplementation in the past with similar results to the above commenter.

It's a pretty common mutation that severely inhibits (depending on how many of the genes are mutated) methylation of folate in the liver. This is an important source of methyl groups for chemical processes, such as those that include NAD.

There's plenty more on Google, including the interaction between an MTHFR mutation and NAD supplementation.

> MTHFR mutation

I'm a geneticist and I still read that as a curse word ...

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