My de facto example of this that I keep coming back to is syntax highlighting. It's immensely useful, and yet once you get used to it, the brain is able to skip the (conscious) step of breaking it down e.g. "this text is green so it means it is a function name, so the next text should be blue because they are function parameters", etc. It's more like "okay, green, blue, bunch of stuff between the braces, checks out". Indentation, squiggly line error highlighting, etc. all serve a similar purpose. They rely on our minds' fundamental ability to recognize visual patterns without having to fully process them through our language centers.
So I feel like there is a huge unexplored space there for more efficient and natural programming. VR with 3D representations of code as, I dunno, pipes, gears, something like that? Function declarations in specific colors and then call sites in mixed colors when one function is called from another? Anything to reduce the friction from thought to working software without having to worry about syntax.
This is all very abstract and I probably haven't explained it well, but it's one of those things I can't shake because I'm fairly sure there's something there.