And what is your second criticism exactly? The author comes from the drug discovery industry. What the author said should be generalized to: even if we know the perfect experimentally confirmed 1A resolution structure of every protein out there tomorrow, that won’t exactly revolutionize drug discovery. That’s because protein structure gives maybe 10% of the context you need to successfully design a drug. It’s dynamics, higher order interaction specifics, complex interplay in signaling pathways in particular cells in particular contexts and what entire cells and organ systems in THAT PARTICULAR ORGANISM do when this protein is perturbed, are what truly affects drug discovery.
If you absolutely want to revolutionize DD, find us a better model to test things on that’s closer to the human body as a whole. Currently mice and rats are used and they’re not cutting it anymore.
This fundamentally goes back to the downfall of the prototypical math or software guy trying to come and say “im gonna cure cancer with MATH!” No you’re not. You’re gonna help, and it’s appreciated, but if you’re gonna truly cure cancer you better start stomping on a few thousand mice and maybe also get an MD.