One word... libc :-) There's tons of info on the internet about the gotchas in Alpine. Even fly.io gave up on using/supporting Alpine based container images and they are probably one of the most competent and capable engineering teams out there.
And yeah libc was a pain for us even for AppImages. You'd think that something as fundamental as C library would be standardized on Unixes...
distroless is picking up a lot of interest especially with its recent uptick in its adoption in the kubernetes community.