It's of course possible to be wrong in either direction -- this difference matters though i think it doesn't and vice versa -- but in general, we tend to be pretty good about taking seriously the things that really are serious, but pretty bad at not wasting time on things that don't matter much. This shows up in the paradox of choice, but really just imagine someone hemming and hawing over two brands of cereal in the aisle at Trader Joe's and you get the picture.
So the practical problem isn't really "how do you know until you analyze," because we more often fall into opposite the trap and waste time systematically attempting to optimize choices where there is little value to be gained. We should step back in more cases and remind ourselves that most differences make no difference at all. Save your time and energy for the ones that do.