You don't need to go that much North - I used to live in Oxfordshire, trying to get to Cambridge for work was a joke (I don't drive). It would take 3.5h+ for a 140km journey from Oxford to Cambridge because train journeys were only through London (+ a railway station change), and there was only one coach that stopped in every town along the way (and which has been axed into two separate legs since the pandemic, making it 4h+ now).
In the end I moved to London, so that's manageable now...