I use screen zoom, which magnifies a portion of my screen around my cursor. As a result, I miss most desktop notifications. I've turned on the thing that flashes the whole screen when they come in, but pan+scanning over to the notifications pile makes me lose context with what I was working on, so I typically ignore the flash too. I should just turn off all the notifications.
There's a lot of "I turn most of them off" here. In parallel, notifications are regularly talked about as a major sticking point around web vs native apps (because Apple). If we, here, aren't using them, why are we building customer-facing tools around them?