I is really well-suited for a broad range of scenarios where your needs are somewhere between a fully static page and a really complex web app.
Although you theoretically can also do the latter, it will get painful very soon, and in that case, my advice would be to combine it with Alpine.js [0]. It can bring some client-side interactivity to your UI and pairs really well with htmx. Recently, someone described their experience using these two here:
https://news.ycombinator.com/item?id=29319034[0]: https://alpinejs.dev/