It would seem with modern automation that you could place relay stations at roughly 250 mile spacings so a driver can pick up a trailer near home, drive 4 hours out, drop off trailer, pick up new one, drive 4 hours back home, drop off trailer, and go home.
This seems like a much easier nut to crack than autonomous driving. Real estate in a lot of flyover country in America is really cheap. And it has other advantages like gasoline and service are at specified points. Basically, treat trailers like IP packets.
What am I missing? (I suspect some sort of CapEx/OpEx accounting tomfoolery that means everybody wants everybody else to take the risk of actually owning things.)