Most of these problems are probably already solved or could be solved. You are of course using dry cleaning services in some form. Fire suppression systems are built in. The structure is quite narrow, so you have a view to the outside from pretty much anywhere, and it's not much worse than any skyscraper, better probably because of (hopefully) better design.

As to social aspects... That is my major concern also. Of course this city has a police force and would clean up anybody blocking the central hubs. There is no street btw, but rather different kinds of corridors for walking and trains of different speeds and ranges. I guess it is relatively easy to disturb the system, on the other hand if realized there would probably be an authoritarian kid of police force making sure nobody does.