Cambridge, UK

- A solid tech hub so you should have enough opportunities

- Good options for your wife as well to work

- You can also work in London (only 50 minutes by train to King's Cross); I do that

- High quality education for kids

While we don't have kids but from friends who do have, they find Cambridge to be great place to work, live and raise a family. And while you won't get warm winters, they should still be manageable if you look at the other positives.