I'll add my anecdote. Nightshade vegetables, in particular the potato, wreak havoc on my body. Took me years to figure out. I didn't even know what a nightshade was. Every few months I'll start to question my sanity and I'm sure potatoes won't bother me. Without fail, every time, rashes, pain, insomnia, deep depressive thoughts, all within 8 hours of consuming potatoes. It's truly crazy. I still have a hard time believing it. Funny enough, I grew up in Idaho, can't eat potatoes. Sweet potatoes it is!