Vitamin D supplementation worsens Alzheimer's progression | Hacker News Reader

Vitamin D supplementation worsens Alzheimer's progression

onlinelibrary.wiley.com

39 pointsnojs16 comments

In Alzheimer mice models, which are completely flawed to begin with. Another pure junk headline.

They also did a retrospective population-based cohort study (no intervention), which is not enough to prove any kind of causality and is prone to confounding factors that can't be easily controlled for (how much time people spend in the sun every day will have a huge impact in their Vitamin D levels and their needs for supplementation or not).

You may well be right.

But there are good and bad mouse models of early onset Alzheimer’s.

The best is the AD-BXD mouse family model of C. Kaczorowski and colleagues. This “model” is genetically diverse—like humans.

Or it might improve the condition: https://pubmed.ncbi.nlm.nih.gov/29447107/

Vitamin D status and risk of dementia and Alzheimer's disease: A meta-analysis of dose-response

Science is hard, and effect sizes matter.

I'm 76. Have declining cognitive function. Have been taking D3 for over a decade. Damn! I don't know what to do other than to experiment with not taking D3.

Try 2-3 gm of niacinamide (non-flushing Vit B3).

This vitamin keeps mitochondria happy.

Start slowly (1 gm/day) and after a month or two ramp up if all is good to 3 gm/day.

It is interesting that the amide form of nicotine is so essential for humans.

”In 1942, when flour enrichment with nicotinic acid began, a headline in the popular press said "Tobacco in Your Bread." In response, the Council on Foods and Nutrition of the American Medical Association approved of the Food and Nutrition Board's new names niacin and niacin amide for use primarily by non-scientists. It was thought appropriate to choose a name to dissociate nicotinic acid from nicotine, to avoid the perception that vitamins or niacin-rich food contains nicotine, or that cigarettes contain vitamins. The resulting name niacin was derived from nicotinic acid + vitamin.”

In a reddit thread I read about the link between the gut biome and different diseases. Someone commented about custom probiotics and that they had seen improvements. They were in the US and they had used flore (I have no idea about them). I think it's worth a try.

Are you a mouse? In that case, you should indeed be worried. If not, just carry on doing what you've been doing.

Get some sun [1]. Might not help, but I bet you’ll enjoy it all the same.

[1]: https://www.outsideonline.com/health/wellness/sunscreen-sun-...

I am 65.

20 years ago I am pretty sure I had declining cognitive functions. At the time I was a good research engineer, but actually I was morbidly obese, was unable to walk 2km (~1.2 miles).

Yet now I think I am better. What changed? I retired, move to an home in a nice rural setting and tried to improve my health through exercise and loosing weight.

I was not easy but I am now able to walk 20km (13 miles) (I even did a 33km round trip). I didn't regain ability to run more than one hundred yards though.

Another thing is try to improve your cardiovascular health, a stroke is something devastating.

Good luck!

Stop eating after 17:00-18:00 pm. If you need to eat, try a banana or a carrot, drink some wine or a beer. Walk a lot, read books or online books a lot.

It may or may not work but this was the best advice from a cardiologist when I was 38.

> Have been taking D3 for over a decade.

Don't take junk headlines at face value. The paper is not very convincing.

Try assessing your Plasmalogen levels.

https://prodrome.com/blood-test/

Hearing very interesting (yet unpublished) results coming out of Dayan Goodenowe's trials of supplementing Plasmalogen precursors on Alzheimer patients. A lot of folks over at APoE4.info have been on the precursors for many months.

https://www.youtube.com/watch?v=mf1Q00QByIA

Get a TDAP shot. It's cheap, low risk, and might help:

SLU Study Finds Lower Dementia Risk in Adult Patients with Tdap Vaccinations

https://www.slu.edu/news/2021/may/dementia-risk-tdap-study.p...

I can't possibly believe any Alzheimer's research right now.

https://www.dailykos.com/stories/2022/7/22/2111914/-Two-deca...

https://www.science.org/content/article/potential-fabricatio...

New territory. Needs really deep research.

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