It's also impossible to do this on almost every other substance we use. I'll focus my energy on avoiding things we know for sure are problematic like refined sugar and get to artificial sweeteners when everything else more important is solved.
This isn't a difficult question.
You should attempt to balance pleasure that has long term risks associated with it.
There is value in not deriving pleasure just as there is value in deriving pleasure. In fact, I don't really know what you mean by "value", but I would not be at all surprised if deriving personal pleasure were found to be orthogonal even to own satisfaction overall.
It's hilarious that you brought this up, because based on wikipedia[1], it the trend actually: it was considered safe until it wasn't ...until it was
[1] https://en.wikipedia.org/wiki/Saccharin#Safety_and_health_ef...
My statement is accurate.
> Remember saccharine? It was considered safe until it wasn't.
That's more true of sugar than saccharine.