I mean, I’m not an expert, but altering the expression of genes already present could be hugely dangerous in theory. These expressions are based on extremely precise feedback loops and interrelationships.
I guess we could use a coding analogy: if you’re using a statically compiled language and you make a code change that compiles and makes the unit tests you have in place pass, it probably works. But it might not… and in this case, what are the risks of the “might not,” especially when we’re layering these modifications on top of each other? And do we need to take such risks?