Vitamin B6 supplements in high doses can calm anxiety and depression

Link to original study https://onlinelibrary.wiley.com/doi/10.1002/hup.2852

"The doses we used were high relative to the RDA; for Vitamin B6 the RDA for adults aged 19–50 is 1.3 mg and the supplement contained 100 mg; for Vitamin B12 the RDA is 2.4 μg and the supplement contained 1000 μg."

(in compare, my okay multivitamin has 50mg B6 and 1000ug B12)

That's an old one:

https://en.wikipedia.org/wiki/Orthomolecular_psychiatry

Unfortunately that article doesn't mention that those folks used B6 as a cure-all because wikipedia often omits pseudoscience knowledge. For instance in their article on Sun Sign Astrology they don't say what the characteristics of a Taurus or Leo are supposed to be.