There is one overwhelming defect that kills illustrator, at least for some of us. It lacks the essential selection mode that Inkscape, Corel Draw, Sketch, and others have: only selecting objects that are totally enclosed by the marquee.
Illustrator insists on selecting everything the marquee TOUCHES. The straight-up stupidity of this limitation becomes obvious as soon as you... well, do almost ANY drawing. Did you do a wireframe of a UI, but want to shift a group of labels? Have fun selecting each one separately instead of just drawing a box around them.
The problem may not sound like a big deal if you don't work with this kind of app, but it is. It's a deal-breaker.