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Comment by wowokay | Hacker News Reader

That’s very interesting. I’m curious how it could relate to humans. Not to say it can’t be 1:1, but there are mental aspects that can effect human hunger and I’d be interested in research around that. For example someone who eats a lot but falls into a depression might slow eating considerably (or eat more depending on the person) it’s not to far fetched to consider the possibility of mind state altering medication that could stimulate the brain causing less or more hungry.

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Absolutely, the mental aspects of hunger are huge, as anyone who has ever had the munchies (super hungry) or taken adderall (super not hungry) can attest.

In fact, n6 fats may also promote hunger, via increasing endocannabinoid production.

Here's a study I just found in mice:

https://pubmed.ncbi.nlm.nih.gov/24081493/

Again just an animal model, but certainly suggestive...

Omega 3 also increases endocannabinoids, but a different form:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685292/

AEA and 2-AG are synthesized from omega-6 polyunsaturated fatty acid (PUFA), arachidonic acid (AA), and are hydrolyzed by fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL),

Herein, we review the discovery and physiological role of omega-3 eCBs that are derived from DHA and EPA (Figure 1A). We illustrate that the derivatization of carboxylic acid end of the omega-3 fatty acid with ethanolamide, glycerol or other groups, such as neurotransmitters, leads to substantial changes in their biological activity and receptor interactions. We also review the discovery, mechanism and activity of the following omega-3 eCBs- DHA-ethanolamide (DHA-EA), 2-docosahexaenoyl-glycerol (2-DHG) and eCB-like- DHA-serotonin (DHA-5HT), DHA-dopamine (DHA-DA) and the EPA analogs.

Very interesting! Thanks. From briefly searching, it looks like 2-AG more specifically may be responsible for increased appetite? I am unsure of the effects of n3 derived eCBs...

> it looks like 2-AG more specifically may be responsible for increased appetite?

That would be my thinking.

These n3 derived eCBs are pretty new so no one knows. But I can tell you, I have found I get "dry mouth" on occasion when I over do the Omega 3. It used to happen more when I took fish oil capsules which I no longer take.

I am also unable to smoke pot becasue it triggers intense anxiety and panic and I think this is becasue I am more sensitive to the THC. And I think this might be a clue how CBD and THC have different psychological effects. THC = Omega 6 and inflammatory and CBD = Omega 3 and anti-inflammatory in a sense.

https://www.sciencedaily.com/releases/2017/07/170718142909.h...

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