This is very nonambitious, but I’d love to see a Clojure with less LISP. That is - something like JS syntax but with immutable by default types and const only bindings. Macros would be great too, even if they require a different compilation mode. Top it off with great standard library that has _all_ the collection operations you’ll ever need (e.g. partition-all and dedupe in Clojure). nREPL support or the like is a hard requirement.
Spending the last 6 years writing Clojure has been great. That said, the parens don’t add positively to the experience. They feel like semicolons in C - “the compiler is too dumb to understand this so I have to help it.”