Definitely. It's interesting to skim the material safety data sheets for commonly consumed chemicals, BTW:

Sugar: http://www.jtbaker.com/msds/englishhtml/s7394.htm ("Extremely large oral dosages may produce gastrointestinal disturbances.")

Capsaicin (in hot peppers): http://www.sciencelab.com/xMSDS-Capsaicin_Natural-9923296 ("Taste: Burning.")

Alcohol (ethanol): http://www.nafaa.org/ethanol.pdf ("May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea.")

Caffeine: http://www.sciencelab.com/xMSDS-Caffeine-9927475

Table salt: http://www.sciencelab.com/xMSDS-Sodium_chloride-9927593