Role of Lactobacillus Reuteri in Human Health and Diseases
ncbi.nlm.nih.gov
ncbi.nlm.nih.gov
I had really bad IBS from consuming water on a tropical island in Panama one time and suffered for a few years with even my doctor friend telling me "Damn that sucks, not much you can do except manage". Pretty horrible symptoms until I discovered L. Reuteri. [1] I read that it's been a bacteria that was more commonly found in samples until around the 1950s when people started consuming more garbage processed food and was sold. Simply stated, it changed my life. It emits a substance called Reuterin which inhibits the growth of other more harmful bacterial species. [2] I can't speak personally for suffering on the level of Crohn's disease, but there's positive research out there regarding it. [3] [4]
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5917019/
[2] https://en.wikipedia.org/wiki/Reuterin
Speaking with one of the researchers he keeps telling me that food diversity and gut microbiome are extremely important for all shorts of things. So your comment doesn't surprise me, I am glad you became better.
Have you never thought about the Pusher and Junkie relationship, at industrial scale? Because that is what Big Pharma is all about.
Basically https://news.ycombinator.com/item?id=32080840 : "some guy" is not good enough.
> American pharmaceutical giant Pfizer Inc. and its subsidiary Pharmacia & Upjohn Company Inc. (hereinafter together "Pfizer") have agreed to pay $2.3 billion, the largest health care fraud settlement in the history of the Department of Justice, to resolve criminal and civil liability arising from the illegal promotion of certain pharmaceutical products, the Justice Department announced today.
https://www.justice.gov/opa/pr/justice-department-announces-...
You should start being a lot, lot more suspicious of claims made by Big Pharma, and start holding them actually accountable for their very real crimes. Anything less is complicity with an industry well-known for exploiting the pusher/junkie equation.
https://www.cbc.ca/news/health/food-cravings-engineered-by-i...
Add in that most food doesn't taste like real food anymore and is engineered to make us crave more:
https://www.vox.com/2015/7/30/9070255/dorito-effect
And you have a perfect recipe for evil.
Big food came into existence thanks to scientific advancements that enabled the world to meet the needs of its population, and that's a good thing. Fertilizers and industrial agriculture has been a massive boon to most of the world, but allowing companies that have private shareholders to commandeer the ship and start steering it in a way that best benefits those shareholders over the best interests of the rest of the world has, in my opinion, created a system that has turned a great good into a perfidious evil.
Another metabolite of L. reuteri is ergothioneine, which is hypothesized to be a "longevity vitamin"[1] by biologist Bruce Ames[2]. Plants and animals cannot synthesize it, only fungi and bacteria, but it is found in every cell in our body including in high concentrations in mitochondria. It appears to be important enough that mammals have evolved a specialized transporter for uptake of this compound (SLC22A4), and mutations in this gene are associated with Crohn's disease.
Low levels of it have been linked to cognitive impairment, CVD, even depression and sleep disorders[3].
Macros aren't everything when it comes to diet, there's a whole universe of micronutrient interactions ongoing in our cells every day. Since we are in a position of relatively near total ignorance, I agree that we should pursue food diversity by default.
[1] https://www.pnas.org/doi/full/10.1073/pnas.1809045115 [2] https://en.wikipedia.org/wiki/Bruce_Ames#Notable_awards [3] https://www.nature.com/articles/s41398-020-0855-1
How does the OP know? Which university was it? Which research group? If "a research group" "found something worked" then there would be a trail of research papers leading up to whatever the patentable invention is.
This anecdote is a complete fabrication: events like this plain do not happen and shouldn't pass the snifftest for anyone: "a professor was paid off" - oh okay, well what about his graduate students? Honors students?
But it's a diet. There's nothing to sell with a diet, so again, what are you talking about?
But you know what let's run with this for a moment because it comes up a lot: you know what happens when a research group has an exciting new X, sells the patent on it and then nothing appears to happen? It doesn't actually work.
This story comes up a lot and frankly, HN should realise it: products are hard, hardware is even harder, try doing bio-anything even more so
There's not a conspiracy, which you are still trying to push with your comments here, the answer is just that it turns out not to work that well. Or that "revolutionary" actually means "minor overall improvement we generally expect from the market".
I am not pushing any conspiracy here, my main points here was that gut microbiome is cutting edge research, and its actually a multi-disciplinary one since most nutritionists don't know a lot about the gut, and most gut doctors don't know a lot about nutrition (at least where I live). IBD is a prime candidate that I know of (but unfortunately I don't have a paper about it, because of whatever conspiracy or corporate greed reason) that can be helped with nutrition. But i've seen papers around talking about mental effects of the gut health too.
https://www.biogaia.com/product-country/biogaia-protectis-ch...
One thing that might interest people on the FODMAP diet is that the first ingredients on the list are isomalt (probably ok) and xylitol (an artificial sweetener). Hopefully the amounts are small enough not to trigger symptoms.
There's also 'Bacilac Femina' which contains reuteri and has less FODMAPs.
Thanks again!
1: https://en.wikipedia.org/wiki/Xylitol#Structure,_production,...
Most people here would doubtless prefer not to science-by-anecdote, but when you’ve got this kind of condition you’re willing to try pretty much anything once.
I’ve heard tell of people “training” kefir grains to uptake other strains of bacteria through repeated exposure during the culturing process. I wonder if you could get a more stable culture by introducing kefir grains to that yogurt for a playdate. I’d imagine some concerted initial exposure plus a periodic Reuteri booster would give you kefir grains that’ll perpetuate the strains you want. Perhaps it would be enough to crush a few tablets in some milk before adding kefir grains, but the yogurt first approach seems easy enough if you have an instapot or other yogurt making device.
1. Turn your oven light on
2. Heat milk to 180F (I heat on Hi to 165F while stirring then turn it down), hold it there for 10 mins. Shoot for 180F but it's not a big deal if it goes to 190F.
3. Cool while stirring in a sink of water to 110F, take it out of the sink.
4. Stir in your starter. I use a popular probiotic on Amazon: open 3 capsules for half gallon of yogurt
5. Ferment in the oven for 24 hours to ensure all sugar is used, making the yogurt lactose-free.
6. Refrigerate
Its kind of a crapshoot if your guts will adjust well or not, and how long it takes for the adjustment to occur.
Just got a box of L. reuteri, hopefully it will make me feel even better.
The chronically ill are. I know people who feel when they don't have their Danone.
Nowadays I just eat kimchi and kraut and hope for the best.
That’s unheard of!
I think it's total nonsense, but the law allows it. If wild bacteria growing on your skin happens to mutate into the exact same genetic code as a patented strain, you could technically be in infringement.
[1] https://internationalprobiotics.org/focus-on-probiotic-paten...
You can buy breast milk from lactating mothers on Craigslist. Good luck.
So no, I wouldn't count on L. reuteri being found in a random sample of breast milk.
But unequivocally showing the existence of entero-mammary pathway (translocation of maternal gut bacteria from the gut to the mammary glands) would be very exciting news indeed.
A seller:
https://cosprings.craigslist.org/hab/d/colorado-springs-brea...
There is nothing sterile in the human body. Not even the brain.
A brain microbiome is hotly debated, no concrete proof (yet?). I personally also have a hard time believing in a healthy bacterial blood microbiota, but it's also proposed.
> It appears to be essentially ubiquitous in the animal kingdom, having been found in the gastrointestinal tracts and feces of healthy humans,[7] sheep, chickens,[8] pigs,[9] and rodents.[10] It is the only species to constitute a "major component" of the Lactobacillus species present in the gut of each of the tested host animals,[11] and each host seems to harbor its own specific strain of L. reuteri.[10][12] It is possible that L. reuteri contributes to the health of its host organism in some manner.[13]
The labs got it from nature, not the other way around.
"BioGaia Gastrus" contains 2 strains of L. Reuteri (DSM 17938 and ATCC PTA 6475)
I crush the tablets to make yogurt following Dr. Davis recipe in SuperGut [1]
[1] https://www.amazon.com/Super-Gut-Four-Week-Reprogram-Microbi...
How long have you been eating the yoghurt? Do you use any other tablets/pills/etc to make it? Why make the yoghurt instead of just eating the pills? What do you think it's done for you?
>>> Do you use any other tablets/pills/etc to make it? No, but there are other recipes in the book than combine different bacteria
>>> Why make the yoghurt instead of just eating the pills? To increase bacterial count; often like x1000 (from millios to billions)
>>> What do you think it's done for you? I did not take it for any particular reason, so I was not expecting much. Most definetively, improved mood after 3 weeks.
> Simply stated, it changed my life. It emits a substance called Reuterin which inhibits the growth of other more harmful bacterial species.
I think taking a single strain is not something you'd want to do long term, I'd assume it's better just as a short course to try and improve your gut bacteria balance, if you're having problems or have just had antibiotics. With a good balanced diet (prebiotic fibre etc.) I don't think people should really need to constantly be taking probiotic tablets, but kefir and yoghurt seem good generally.
I’ve had a lot of kefir grains from different sources over the years, and many that you order online seem to be weak and not thrive. By contrast, I’d gotten some big healthy grains from a friend of a friend who’d been culturing them in raw milk in rural MT for a lot of years, and those things were monsters that grew large and divided often. They led me on an on- again off-again quest to find such excellent grains.
I’ve heard of people introducing their grains to e.g. Icelandic skyr cultures, which results in the permanent colonization of the kefir grains by particular microbes. The skyrified kefir being qualitatively different. I could see getting a lab strain of reuteri and similarly training kefir grains to incorporate this as part of the colony.
I'm actually super interested in learning how to make yogurt with it now to help people I know who may be suffering out some. I hear that's a really easy way to make it even more bioavailable. Proper respects to the people who brought this up! [1]
It's not astroturf, I dunno why I'd spend like a year on this site mostly talking about tech stuff and then just drop that I've had the most horrible shits of my life cured, that's kind of a really personal thing I'm only sharing here because it was extremely helpful to me - and I only hope it works for others, but that hope is strong enough.
[1] https://www.luvele.com/blogs/recipe-blog/how-to-make-l-reute...
I recommend getting a sous vide device for precise temperature control. Initially, I used a the "Yogurt" function on an Instant Pot pressure cooker and about half of the batches failed, separating into whey and curds.
- I buy full fat milk in a glass bottle so that I can make the yogurt directly inside without having to sterilize another container. I have had more success with UHT milk than pasteurized milk.
- I add two tbsp. (~40g) of my previous batch to one liter of milk. Close lid and shake.
- Put bottle in a pot of water, submerging most of the milk bottle. I leave the lid on, but untightened so that gas can escape.
- I add a sous vide "wand" to the pot and leave it for 24 hours at 38°C (100°F)
I deviate from Dr. Davis' recipe by not adding inulin to the milk and fermenting for a shorter duration. This probably results in fewer bacteria present in the final product, but the above takes me less than 5 minutes to prepare.
I have kidney disease, and cannot take the usual gout prophylactic medications.
I read that in Japan there is a 'gout yoghurt ', called Meiji (I think) and bought some l. gasseri to try making myself.
I also see a list that includes sourdough bread, wine, beer, certain cured meats, kimchi, kombucha tea, miso soup.
Not sure about wine I thought they didn’t something to stop the yeast fermenting. I know once bottled the process has stopped for wine and beer.
There are also ways to remove them entirely by using clearing agents/finings followed by racking (siphoning from the primary fermentation container to a new container) - this is the normal process.
If you are doing natural carbonation or "secondary fermenting" in the bottle by leaving some yeast in and back sweetening, you can kill the yeast by pasteurizing in-bottle (basically by putting the bottles into a pot of hot water for a while). Though this does sometimes lead to explosions.
Its not like we would normally capitalize "Human" or "Health" either?
> In modern usage, the first letter of the generic name is always capitalized in writing, while that of the specific epithet is not, even when derived from a proper noun such as the name of a person or place. Similarly, both parts are italicized in normal text (or underlined in handwriting).
Which is kind of confusing to me as when i tried to look it up in style guides, they seem to indicate that all nouns should be capitalized in a title, e.g. https://apastyle.apa.org/style-grammar-guidelines/capitaliza...
> When an animal name is part of a journal article title, it is conventional to provide the animal’s scientific name (genus and species). Genus is always capitalized and species is not. Notice that the scientific names are also italicized
[1] https://blog.apastyle.org/apastyle/2017/02/-how-to-format-sc...
What the hell?