> as well as testing the drug on a real creature

Please re-read my original comment. In particular, the 92% bit

> you have to test on a full organism

Are you suggesting testing on humans? Clearly that's the only way to clear those "surprises".

> Organoids just don't have the complexity of living creatures

I think the gist of my argument against animal testing is that animal models aren't very good at predicting outcomes in humans.

Furthermore, there have been some disasterous human clinical trials where drugs have passed all the animal model testing but left many of the human participants dead.