[1] https://en.wikipedia.org/wiki/Clipper_(programming_language)
[1] https://en.wikipedia.org/wiki/Clipper_(programming_language)
They like consistent, reliable, fast operation. Especially those first two things.
The things that make them most unhappy are: 1) programs that behave unpredictably—a predictable, consistent bug that happens every single time is preferable to an operation that fails 5% of the time, randomly, or a button that fails to register about half of all clicks, or anything like that and 2) changes to an interface they've already learned—because your new thing probably isn't 1/10 as "intuitive" as you think it is, so it's just another annoying arbitrary thing they have to deal with for no good reason, when they already had the last annoying, arbitrary thing figured out.
Now, where it might make a difference (maybe—but I'm skeptical) is screenshots on sales pages. Which I suppose is why design continues to be so anti-user.
wxWidgets applications are supposed to look native on every platform... what's the issue? Personally, I find apps with weird GUIs that don't look at all like the rest of the system very irritating. I would prefer developers to spend more time implementing features, and less making bling-bling UI things.
So many apps twenty years ago had features that apps today do not. It was really frustrating to see instant messaging services regress in features as people migrated from one to another to a third to ... today's dumpster fires.
My main point is that "native" covers a lot of ground, and "native legacy compatibility" and "native modern" are radically different technology stacks on Windows.
Of course since they come with the OS you might as well use those instead of bundling a separate UI toolkit, but IMO if you consider them as native as the HWND stuff then might as well consider everything native - AFAIK Windows even comes with a shared Electron/Chromium instance applications can use so in that case you could say anything that uses Electron is native on Windows :-P.
In practice, Qt looks much more native on Gnome than GTK does on KDE so you should go with Qt.