I wonder what the impact of knowing you can leave at any time is... Well, short of imprisoning them I guess this is the closest we can get to simulating the experience.
Perhaps a way to do it and remove the ability to leave would be to send them to the International Space Station for an extended period ... (still cheaper than a trip to Mars!)
The trade-off, I guess, is that the simulation becomes more real when one incorporates the very real dangers of space.