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Indoles in general are common gut metabolites and an indole proprionate sounds like a further metabolic product.

This leads me to believe that trying to increase indole-3-proprionate specifically may be a fruitless journey (pun not intended), and one would be better off by optimizing for a hospitable environment for beneficial microbes in general, for example by cutting out carbs but increasing intake of flavonoids.

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I suspect you may be right. Many supplements that have been tried just get broken down in digestion and don't actually increase target levels in the target tissues, rather we need to find ways of increasing the intake of precursor or figuring out which microbiota are involved in the metabolism and giving them a helping hand or just adding them altogether

I don't have a citation handy but I know eating fermented foods and increased fiber have both been linked to increased gut bacteria diversity. Thus seems in line with what the GP poster found for practical advice.

Its all about PREbiotics which are the food source for probiotics or your gut bacteria. Which encompasses some fiber and also sort of is its own thing. Long chain inulin and resistant starch are both some good ones

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