Alopecia areata after SARS-CoV-2 vaccination | Hacker News Reader

Alopecia areata after SARS-CoV-2 vaccination

ncbi.nlm.nih.gov

25 pointsBandOfBots14 comments

"In summary, here we show that the LNPs used for many preclinical studies are highly inflammatory. Thus, their potent adjuvant activity and reported superiority comparing to other adjuvants in supporting the induction of adaptive immune responses could stem from their inflammatory nature. Furthermore, the preclinical LNPs are similar to the ones used for human vaccines, which could also explain the observed side effects in humans using this platform." - ["The mRNA-LNP platform’s lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory" (2021)](https://www.biorxiv.org/content/10.1101/2021.03.04.430128v1....)

If the shortened emergency FDA process for covid vaccines is "safe" then it should be considered safe for other products as well. If its not safe, then it should be no safe for the covid vaccines as well.

tl;dr - the testing process is the same.

The EUA process simply allows manufacturers to build out the products while they are testing, as opposed to doing it in serial:

https://healthtalk.unchealthcare.org/whats-the-difference-be...

In general, COVID vaccines have been far more extensively studied than any other vaccine has ever been.

There is a problem - with every single possible authorized medicine - that there may be long-term longitudinal issues that are uncovered, especially when the entire world is the population study.

>COVID vaccines have been far more extensively studied than any other vaccine has ever been

By what measure?

By pretty much every imaginable measures: number of papers, number of researchers, sample size, size of the control group exposed to the disease …

The only lacking aspect is the long term effects, because by definition we don't have long term hindsight (but no vaccine has it before being commercialized, by definition).

>The only lacking aspect is the long term effects, because by definition we don't have long term hindsight (but no vaccine has it before being commercialized, by definition).

I'm not sure I understand this sentence... are you claiming no other vaccine had more data on long term effects prior to commercialization than the covid vaccines?

By all measures - population size, number of studies, number of meta-studies, number of phase 1/2 studies. Number of doctors, number of skeptics. Number of papers.

>Population size

By population size, do you mean the number of people in the general public who have taken the various covid vaccines under the FDA EUA?

No, the testing process is not the same. See the “data gaps” section in the FDA’s EUA review for Pfizer’s vaccine [1].

[1]: https://www.fda.gov/media/144416/download

The safety under 16 resulted in it not being issued in U16 until it was studied. The longitudinal I referred to above - no one effectively does this today, and it's not really possible to do it under the current FDA licensing structure. No vaccine-enhanced disease has been detected.

Safety is not black and white; everything is a tradeoff. If COVID was say, 100x worse, I think it would be obvious that it would be worth the risks of an expedited process to release a vaccine sooner.

Nearly 2% of unvaccinated people died of covid complications.

If left unchecked, not counting for the fact that getting covid once does not preclude you from getting it again, that would mean roughly 140,000,000 of the people alive as of 2019 would die from covid related complications during their lifetimes.

If it were 100x worse, it would eradicate the human race.

Right now, the death toll is approximately 6.3 million. I think a few million early choking and gagging deaths by suffocation is worth the small risk of having a complication from the vaccine, of which, nearly 2 years in so far the worst complication is an inflamed heart.

>If the shortened emergency FDA process for covid vaccines is "safe" then it should be considered safe for other products as well.

Absolutely ridiculous logic. Minor side effects of a life-saving vaccine is absolutely not something that should be allowed for other products that wish to jump regulations and safety.

So basically you’re saying we must always go through the full rigid bureaucratic process with no exceptions, flexibility, or consideration for urgent sudden crises that are outside the scope the standard process was designed for.

And actually beyond that, the process that is supposed to take care of time sensitive emergencies is to be ignored, I.e. emergency use authorizations.

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