Donations clear the blood of stuff like cholesterol and microplastics, so the first donation can leave one feeling better the next day. Donating twice a week can be more taxing on the body and result in stuff like a lower body temperature, slower heartbeat and lower blood pressure because the heart doesn't have to work so hard to pump thinner blood.
I'm mostly concerned about using up the body's regenerative ability, since nobody knows how many times that plasma can be synthesized over a lifetime. But many of the components in blood have a natural recycling rate anyway. I suspect that the body can't tell if it's building new plasma from old plasma or nutrients in food though.
Without more evidence, I feel that it's better to rely on the expertise of the medical community than speculation. Just my two cents, YMMV.
> It is healthy to donate once or twice each week, if there is a 48-hour period between each donation. Plasma is 90% water and frequent donation will not harm you. It can lead to side effects such as dizziness and fatigue, but staying hydrated can help avoid these.
HAVE YOU lately experienced a craving for chocolate milk? If you’re lucky, it’s just a symptom of lactose intolerance. If you’re less fortunate, there’s a serious glitch in the space-time continuum.