My niece was born without legs, and only one arm. She has a wheelchair that can be operated with one hand. It has the 2 metal push bars fitted to one side of the chair. The left bar is connected to the left wheel, the right bar to the right wheel. You can grab both with one hand. By moving both at the same time you go straight, or grab one ring to steer. It works really intuitively.
I believe this one-hand option was custom designed for her use-case (which would be about 30 years ago now), but since then many other people that have both arms tried her chair, and immediately contacted the manufacturer to order a chair with the one-hand option. AFAIK the manufacturer now offers the one-hand option on all their chairs.