Gas Fracking may cause earthquakes
sfgate.com
sfgate.com
Saying "but if fracking can cause small earthquakes, might it not one day cause a large one" is a bit like saying "if your cat can devour a mouse, how do we know it won't one day devour an entire city?"
[1]:http://www.woai.com/news/local/story/Could-fracking-be-at-fa...
The conclusion was that removing material from underground and not replacing it with supporting structure causes subsidence, and depending on the structure, punctuated subsidence which is basically code for an earthquake.
Draining aquifers has a similar effect although the rate at which an aquifier is drained is less noticeable.