Not really. It messes with DNS big time. Try enabling the "MagicDNS" or "Exit Nodes" features, and watch as /etc/resolv.conf is edited with each change. I can easily reproduce scenarios where it's left empty and there's no working DNS resolution.

This is one of the major things I _don't_ like about Tailscale. I wish they'd just stick to enabling Wireguard and making the authentication easier (i.e., where they started). I'm not a fan of most of the features they've added since. I don't want service discovery, magic DNS, SSH key management and/or the kitchen sink bolted on.