A multi-region AWS architecture for low latency edge messaging
ably.com
ably.com
But I hope it's valid because, if you try to build a multi-region system for low-latency data transfer across regions, there are issues like discovery and synchronisation to consider.
I think it may be interesting to see how Ably is architected so its pub/sub messaging is realtime and reliable.
For example, how do the EC2 instances in one region find those in another? How does a published message in one region get to a client subscriber in another?