So many potentially-interesting channels have lost me because two minutes into the first video I try, they're still talking about previous videos or irrelevant personal stuff or their subscriber count or WTF ever. Close tab.

You have sponsorblock[0] to at least skip the ads and the remainders to "like and share and subscribe". It works really well.

However, youtube premium might be the solution if you want to support your favorites channels without ads.

[0]https://addons.mozilla.org/en-US/firefox/addon/sponsorblock/

Descript probably fits the bill: https://www.youtube.com/watch?v=Bl9wqNe5J8U

HN had some good discussions last year with alternatives: https://news.ycombinator.com/item?id=25641205

You can use revoldiv.com to cut out filler words or any words of your choosing, after you upload your file and it finishes sound detection, you can click on the search box to bring up the toolbar to delete sounds