The foldit [0] game has players solving protein folding problems that have real world implications. More ideas in this angle would be data labeling type situations to power machine learning systems. These are currently done through MechanicalTurk or large offices in low cost areas of the world dedicated to the task.

The tools are not usually that polished or that pleasant to use, and don't have the same gamified and reward angle. So if you could figure out how to package the work, add some whimsy, and cross validate results you might have something.

0 - https://fold.it/