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The technology that drives this is undoubtedly very interesting, but what does this truly offer? What would be the practical application of this?

Are there droves of people who could benefit from constantly changing css?

Perhaps I'm just missing something rather obvious. If so, please help me.

Quickly switching of themes is one reason why you would want to make it easy to change css: http://xavi.co/articles/jquery-ui-css-themes-hosted-on-cdn

I can also be quite useful during development. One cool trick to achieve something similar is to add a contentEditable attribute to a style tag: http://css-tricks.com/8618-show-and-edit-style-element/

Everyone who does web development benefits from this, starting with myself. Have your browser side-by-side with your editor, save your CSS, boom.