I would not wish Matlab GUI programming on my worst enemy. I disagree with your assertion that documentation for Python is typically much better. Take a randomly chosen function I regularly use: "pwelch"

https://docs.scipy.org/doc/scipy/reference/generated/scipy.s...

https://www.mathworks.com/help/signal/ref/pwelch.html

Maybe my bias is showing, but I find the Matlab documentation to be superior. However, that is nothing compared the quality of the IDE which is critical when doing scientific compute. When I was re-evaluating our simulation environment at work, we looked at PyCharm. The plotting capabilities alone made it easy to stick with Matlab, even at the orders of magnitude higher cost.

N.B. This is my experience in an Optical Communications R&D environment.