Nuclear pore complex by integrative cryo-EM and AlphaFold

For context, the nuclear pore complex is one of the largest structures inside a human cell. Using AlphFold and some special microscopy, researchers were able to simulate a model of the nuclear pore of an African Claw frog egg (the frog eggs are easier for researchers to "see" without much intervention and tend to contain many nuclear pore complexes per egg).

This is an important results since they're a rather important structure and have been linked to a few diseases in humans, but because of their complexity, they've been difficult to model, despite some efforts over the past 20 years.

Now, for the first time, thanks to advances in machine learning, we know what they look like. At least in the frog version. And have a general approach for modelling protein structures in the future.

It's a great day for science.