If you saw an old lady carrying shopping bags you’d feel no risk of danger vs a large male in a hoodie walking in a weird way and looking at you.
Who's to say it's not a large "adolescent male human"?
I don't think the comment above had anything to do with trans activism. It had to do with whether you sound like a creepy robot.
Or when referring to non living things "Male USB connectors" or "Male protagonists".
But I don't think it's normal to refer to your fellow humans as male or female outside of those contexts.
At least that's what I've picked up via cultural osmosis.
It's common in deliberately dehumanizing contexts; you’ll see it a lot historically (in writing, we don't have audio recordings) in the context of the slave trade, it's used as distancing language by law enforcement, and “female” became somewhat common among people who talk about women-as-possessions from about the late 20th century.