Which didn’t remain so neutral when applied to fresh populations.
Native Americans simply weren’t playing host to as many diseases, and persisting virulent ones
Imagine a hit man showing up to work one day, only to find his targets already dead along with their entire town... and only much later finds out that it's because he'd been an asymptomatic carrier for weird space germs when he was casing the joint the previous month.
The intent in this case existed alongside unintended causes, but it was still there.
[0]https://en.wikipedia.org/wiki/Spanish_conquest_of_the_Aztec_...
[1]https://en.wikipedia.org/wiki/Spanish_conquest_of_the_Inca_E...
Maybe an oversimplification to assert "the Europeans didn't topple any empire in the Americas"?