Comment by shagie | Hacker News Reader

Comment by shagie | Hacker News Reader

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> I've always wondered how far off we are from being able to "3D print" tastes and smells. I had a machine learning professor tell me that chemoreception is the only sense that can't be decomposed into "eigensmells" or "eigentastes" - not sure if that still holds true today.

This gets into an interesting and controversial (in that scientists will argue about it) domain.

Smell may be detecting the quantum vibrations of electrons.

2011: Flies sniff out heavy hydrogen - https://www.nature.com/articles/news.2011.39

2013: 'Quantum smell' idea gains ground - https://www.bbc.com/news/science-environment-21150046

2019: Human smell perception is governed by quantum spin-residual information - https://aip.scitation.org/doi/10.1063/1.5121155

https://en.wikipedia.org/wiki/Vibration_theory_of_olfaction

And for the other take on it:

2015: What’s that smell? A controversial theory of olfaction deemed implausible - https://theconversation.com/whats-that-smell-a-controversial...

Tangentially to the fly test: 2021: Heavy water tastes sweeter - https://www.pnas.org/post/journal-club/heavy-water-tastes-sw...

> And in a taste test with noses plugged, over half did, suggesting that taste receptors on the tongue were indeed picking up the subtle flavor.

There's some work on using ML methods to map from the structure of a molecule to an odor. Interesting to see where it goes, current results aren't that mind blowing:

1. B. Sanchez-Lengeling, J. N. Wei, B. K. Lee, R. C. Gerkin, A. Aspuru-Guzik, A. B. Wiltschko, Machine Learning for Scent: Learning Generalizable Perceptual Representations of Small Molecules. arXiv [stat.ML] (2019), (available at http://arxiv.org/abs/1910.10685).

2. J. Kowalewski, B. Huynh, A. Ray, A System-Wide Understanding of the Human Olfactory Percept Chemical Space. Chem. Senses. 46 (2021), doi:10.1093/chemse/bjab007.

3. L. Shang, C. Liu, F. Tang, B. Chen, L. Liu, K. Hayashi, Odorant molecular feature mining by diverse deep neural networks for prediction of odor perception categories. bioRxiv (2022), , doi:10.1101/2022.04.20.488977.

I suspect that might be harder than it sounds. See this (circa 2014) Aussie chemistry teacher's crowdsourced organic compound perceived-smell infographic -- it seems pretty random.

[0] https://jameskennedymonash.wordpress.com/2014/01/04/table-of...

My favorite part of the vibration theory... from the Wikipedia article:

> Carvone presented a perplexing situation to vibration theory. Carvone has two isomers, which have identical vibrations, yet one smells like mint and the other like caraway (for which the compound is named).

> An experiment by Turin filmed by the 1995 BBC Horizon documentary "A Code in the Nose" consisted of mixing the mint isomer with butanone, on the theory that the shape of the G-protein-coupled receptor prevented the carbonyl group in the mint isomer from being detected by the "biological spectroscope". The experiment succeeded with the trained perfumers used as subjects, who perceived that a mixture of 60% butanone and 40% mint carvone smelled like caraway.

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