Why try to predict the future and forget the past? John McCarthy proposed GC in the 60s, and we had operating systems in the early 80s implemented in GCed languages. See, for example, Symbolics Genera (lisp) or Smalltalk-80. Xerox Cedar/Mesa based OSes too. Pretty sure Perq POS was GCed (heavily enhanced Pascal) but don't remember for sure.

So, yes, if it makes sense, you can write drivers, operating systems, databases, browsers and games etc.