"Finally, one must address the concerns of various commercial stakeholders."
"A few chemical databases of reactions do exist, but these are commercial (e.g., Beilstein/Reaxys [Elsevier], SPRESI [InfoChem], and CAS [ACS]), and even when a license is purchased, the underlying data are accessible only through a narrow, one-query-at-a-time interface, completely stifling the application of powerful artificial intelligence and machine [...]"
This seems like the first point of approach, not the last. Can anyone comment why these data gatekeepers have not made a business model to give programmatic access to nerds?
And if they have financial reasons for not doing so, how will governments sweet talk shareholders into supposedly losing money?