Also with the size of the rocket the proportional air breathing machinery power scales between linear and square while rocket mass cubically, so a useful air breathing on say a Starship is hard to imagine.
Payload size is clearly a massive problem because airplanes are so volume limited. But there is another issue here: heating. In order for an air-breathing engine to provide useful thrust, you have to have enough air for it to breathe. That pretty much requires you to now have to deal with aerodynamic heating, which is a thing that most rockets try very very hard to ignore on launch.
The most prominent air-breathing to orbit attempt going right now, Skylon, seems to be viewed generally pretty skeptically by most people in the space community, from what I can tell. And even then, the log-line is different: instead of separate jet engines and rocket engines, the idea is to have a rocket engine that can make a mediocre jet engine for some portion of the flight. Most people outside RE don't think this idea will work very well (I recall people who ran the numbers pointing out that HOTOL- the program that Skylon grew out of- would actually have significantly more payload if it had just rocket engines) but Bond and co. continue on, with very small budgets, the sort of budgets suitable for long-shot technology development. Thus, it appears that the people who control the purse strings generally agree that this has a low chance of working out, even if it is worth trying.
I haven't done the math, but in general, the benefit of something like stratolaunch is much less than you'd expect
Here's a great (but complicated) reddit post on this topic:
https://www.reddit.com/r/KerbalAcademy/comments/63nzq6/how_d...