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Microchip has been copying Cypress in new ATSAM* microcontrollers, with op-amps and comparators on the chip. I think this is about as far as programmable analog circuits will get in mainstream applications. Just adjust your signal to a good amplitude for an ADC, and do everything else digitally.

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See also https://anadigm.com/ (which styles itself as "The FPAA Company" where 'FPAA' is Field Programmable Analog Array) and https://www.dialog-semiconductor.com/products/greenpak (GreenPAK™ originated with Silego Technology, which Dialog bought in 2017, Dialog itself is now part of Renesas as of last year).

The GreenPAK line includes a variety of ICs, some of them are more like traditional FPGAs and some have analog components too.

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